EGO PGX1401PB handleiding
Handleiding
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Test (OECD Guideline 473, GLP)) and in vivo (DNA damage, chromosome aberration and micronuclei
induction test)
- Boehmite (Al(OH)O): Negative reactions were observed in vitro(mammalian cell gene mutation
assay(OECD TG 476, GLP), Negative reactions were observed in vivo Mammalian Erythrocyte
Micronucleus Test (OECD TG 474, GLP)
- Carbon black: Negative reactions were observed in both in vitro (Bacterial gene mutation test(OECD TG
471, GLP), Chromosomal aberrations test (OECD TG 476)) and in vivo (DNA damage and/or repair test).
- 1-Methyl-2-pyrrolidinone: Negative reactions were observed in both in vitro (Chromosomal aberrations
test (OECD Guideline 476, GLP)) and in vivo (Mammalian Erythrocyte Micronucleus Test (OECD Guideline 474,
GLP)).
- Chromium: In vitro mammalian chromosome aberration test, the result of the assay was negative. (Read across;
stainless steel)(OECD TG 473, GLP)
- Lithium carbonate;Lithane: Negative reactions were observed in vitro (Bacterial Reverse Mutation Assay(OECD
Guideline 471, GLP)).
- Ethylbenzene: Negative reactions were observed in in vitro-mammalian chromosome aberration test (OECD TG
473), mammalian cell gene mutation test (OECD TG 476, GLP) and in vivo-unscheduled DNA synthesis (UDS)
test with mammalian liver cells (OECD TG 486, GLP), mammalian erythrocyte micronucleus test (OECD TG 474,
GLP).
Reproductive toxicity:
-Graphite:
- Copper: In reproductive toxicity with rats, there were no effects considered (up to 1500 ppm). (OECD TG 416,
GLP)
- Aluminum: No reproduction, breeding and early post-natal developmental toxicity was observed in rats at 1000
mg/kg bw for males and females. (OECD TG 422, GLP)(Aluminium chloride; read across)
- Lithium hexafluorophosphate(1-): In the two-generation reproductive toxicity with rats, no effects observed on
reproductive toxicity. (male/female)(OECD Guideline 416, GLP)(OECD Guideline 414)(Information on major
hydrolysis product of the registered substance (released rapidly on contact with water/moisture))
- Boehmite (Al(OH)O): No reproduction, breeding and early post-natal developmental toxicity was observed in rats
at 1000 mg/kg body weight for males and females.(OECD Guideline 422, GLP)
- Carbon black: No adverse effects on the reproductive function are expected.(OECD TG 414)
- Chromium: In the 90 days inhalation toxicity study using rat, there were no effects on clinical signs,
mortality.(OECD TG 413)
- Ethylbenzene: There were no adverse effects on reproductive or developmental endpoints at dose levels up to 500
ppm EB in this guideline two-generation rat inhalation study. OECD TG 416, GLP);
Results of prenatal Developmental Toxicity tests for rats, litter size was comparable between the treated and control
dose groups, while a statistically significant dose-related reduction in fetal weights were noted in the 1000 and 2000
ppm dose groups. Visceral malformations occurred in one or few fetuses from the 100, 1000 and 2000 ppm exposure
groups, without a clear dose relationship and no statistical significance. NOAEC = 2000ppm (OECD Guideline 414)
Specific target organ toxicity (single exposure):
- Fe: If inhaled, iron is a local irritant to the lung and gastrointestinal tract.
- Copper: All animals showed expected gains in bodyweight over the study period and there were no
abnormalities noted at necropsy. (OECD TG 423, GLP)
- Aluminum: In test using rats, Clinical signs of depression, laboured respiration, piloerection and hunched
appearance was noted at the highest dose 15900 mg/kg. Macroscopic examination at the end of the
observation period did not reveal any aluminium-related changes of the internal organs of the aluminium
treated animals compared to the control group. (OECD TG 401)(Fumed alumina; read across)
- Lithium hexafluorophosphate(1-): Clinical signs observed during the study period were lethargy, hunched
posture, uncoordinated movements, piloerection at 300 mg/kg, hunched posture, piloerection at 50 mg/kg.
The surviving animals had recovered from the symptoms by Day 3.(OECD Guideline 423, GLP)
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Productinformatie
| Merk | EGO |
| Model | PGX1401PB |
| Categorie | Niet gecategoriseerd |
| Taal | Nederlands |
| Grootte | 3256 MB |
